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Cationic Peptides for Intracellular Delivery of Bioactive Molecules

Cationic Peptides for Intracellular Delivery of Bioactive Molecules

Description:

Unmet Need: Rapid and efficient cell penetrating peptides

Currently available cell penetrating peptides (CPPs) are inefficient and show slow cell uptake. There is also a major issue blood plasma stability. They are stable only around 15 -30 min. There is a need to design better efficient and stable CPPs.

The Technology: Unnatural cationic cell penetrating peptides

WSU researchers have developed a new class of cationic cell penetrating peptides called SialoPen that offers a new strategy of delivering molecules into mammalian cells. These peptides have the properties of an ideal intracellular carrier of bioactive molecules, most notably for introducing genes into cells to understand cellular function, with potential future applications in gene therapy. These peptides, prepared synthetically from the sugar amino acid called sialic acid, possess an outstanding ability to cross the plasma membrane of HeLa cells and primary neuronal cells, with uptake efficiency of 5- to 10-times than standard CPPs.

Applications:                                           

•       Gene therapy

•       Drug delivery

Advantages:

•       Greater efficiency (5-10 times) to penetrate HeLa and neuronal cells as compared to standard CPPs.

•          Significantly higher rate of cell uptake.

•    Resistant to degradation by blood plasma proteases hence increased peptide bioavailability and stability.

Patent Information:

US patent application filed(US-2016-0361396-A1): https://www.google.com/patents/US20150361396

Patent Information: