Hydrogen Sulfide Releasing Agents

Abstract

Hydrogen sulfide (H2S) has demonstrated several essential critical care benefits when delivered properly in low doses. The current state of the art delivery systems rely on gaseous delivery of H2S to patients. WSU researchers have developed chemical agents that controllably decompose to release H2S and demonstrated their efficacy in biological tissues. 

Applications and Advantages

§   Timed-release 

§   Biocompatible

IP Status 

US patent application pending and PCT/US2011/062820 published as WO2012/05242

Publications

Zhao, Y.; Wang, H.; Xian, M.; Cysteine activated hydrogen sulfide (H2S) donors. J. Am. Chem. Soc.,  2011, 133, 15.

 

Zhao, Y.; Bhushan, S.; Yang, C.; Otsuka, H.; Stein, J.D.; Pacheco, A.; Peng, B.; Devarie, N.O.; Aguilar, HC; Lefer, D.J.; Xian, M.; Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury.  ACS Chem. Biol. 2013, in press.

 

See trade magazine article at: http://cen.acs.org/articles/91/web/2013/04/Hydrogen-Sulfide-Donors-Protect-Heart.html 

 

Learn More

Punam Dalai
Technology Licensing Associate
Washington State University
(509) 335-1216
punam.dalai@wsu.edu
Reference No: 1086-OC

Inventors

Ming Xian
Hua Wang
Yu Zhao

Key Words

Chemistry