Office of Commercialization Search Results - philip+lazarus

Search Results - philip+lazarus

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Prevention of cancer treatment-related heart toxicity
Unmet Need: Effective strategies to prevent cancer treatment related cardiotoxicity. Anthracyclines are currently the cornerstone of many modern chemotherapy regimens. For example, Doxorubicin (DOX, trade name Adriamycin), is frequently used to treat hematological malignancies and solid tumors. Unfortunately, administration of DOX also causes cumulative...
Published: 2/17/2020   |   Inventor(s): Zhaokang Cheng, Philip Lazarus
Keywords(s): Pharmaceutical, Therapeutics
Novel P450-overexpressing cell lines
Unmet Need: Current market do not have P450-overexpressing cell linesCytochromes are the major enzymes involved in drug metabolism, accounting for about 75% of the total metabolism. Most drugs undergo deactivation by Cytochromes P450 (CYPs), either directly or by facilitated excretion from the body. CYPs is a superfamily of are highly polymorphic enzymes,...
Published: 2/21/2018   |   Inventor(s): Philip Lazarus, Amity Peterson
Novel agents for smoking and tobacco cessation
AbstractNicotine is the molecule responsible for the psychopharmacological effects and the addictive properties of tobacco use and cigarette smoking. Researchers at Washington State University have developed an orally-available nicotine derivative that can be prescribed for the cessation of cigarette smoking and tobacco use. It specifically inhibits...
Published: 2/21/2018   |   Inventor(s): Philip Lazarus, Travis Denton, Gang Chen, Pramod Srivastava, Alec Wynd, Zuping Xia, Christy Watson