Treatment for aggressive chemotherapy-resistant prostate cancer Unmet Need: Treatment of aggressive chemotherapy-resistant prostate cancer Prostate cancer (Pa) is a current epidemic that affects roughly 1 in 9 men. While treatment of early stages of this disease are very successful, a small percentage of patients have a recurrence of the disease that is much more aggressive. Current second line therapies include anti-androgens and chemotherapy yet eventually the disease becomes resistant to both therapies. Chemotherapy-resistant prostate cancer (ChRPC) remains a leading cause of cancer-related deaths in men as there are currently no therapeutics for PCa once it becomes resistant to chemotherapy. The Technology: Combining antimuscarinics with chemotherapy agents Researchers at WSU propose that the muscarinic acetylcholine receptors 1 and 3 (CHRM1/3) signaling leads to the development and maintenance of chemotherapy-resistant PCa. They discovered that pretreating ChRPC cells with antagonists of CHRM1 or CHRM3 before treatment with the chemotherapy agent docetaxel (DTX), re-sensitizes these cells to DTX-induced cell death in vitro. Applications: • Treatment of chemotherapy-resistant prostate cancer. Advantages: • Pretreating chemotherapy-resistant PCa cells with antagonists of CHRM1 or CHRM3 before treatment with DTX enhances DTX-induced cell death in DTX sensitive cells and re-sensitizes DTX-resistant cells to DTX in vitro. Patent Information: Provisional patent application filed Learn More Punam Dalai Technology Licensing Associate Washington State University (509) 335-1216 punam.dalai@wsu.edu Reference No: TECH-19/3256 Bookmark this page Download as PDF Inventors Boyang Wu Tyler Bland Baron Bechtold Karen Vo Key Words Cancer and aging Therapeutics