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Mice with humanized telomere homeostasis
Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis
Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...
Published: 1/9/2024
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Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng
Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase
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Paper-based cationic isotachophoresis for lateral flow immunoassay development
Unmet Need: Improving sensitivity and specificity in Lateral Flow Immunoassays at low concentrations
Lateral flow immunoassays (LFIAs) are among the most popular diagnostic platforms on the market due to ease of use and capacity for antigen detection in diverse biological samples. However, they are often critiqued for their relatively high limits of...
Published: 9/21/2023
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Inventor(s): Wenji Dong, Devon McCornack
Keywords(s): Adsorption, Applied Technologies, biosensors, Biotechnology, Cancer and aging, Cationic Isotachophresis, depletion of abundant serum proteins, Nanotechnology, Purification, Real time virus sensor
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Treatment for aggressive chemotherapy-resistant prostate cancer
Unmet Need: Treatment of aggressive chemotherapy-resistant prostate cancer
Prostate cancer (Pa) is a current epidemic that affects roughly 1 in 9 men. While treatment of early stages of this disease are very successful, a small percentage of patients have a recurrence of the disease that is much more aggressive. Current second line therapies include...
Published: 4/28/2023
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Inventor(s): Boyang Wu, Tyler Bland, Baron Bechtold, Karen Vo
Keywords(s): Cancer and aging, Therapeutics
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