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Mice with humanized telomere homeostasis
Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis
Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...
Published: 4/8/2026
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Inventor(s): Jiyue Zhu, Fan Zhang, De Cheng, Shuwen Wang
Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase
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New Oilseed Remodeling
Unmet Need: Improved fatty acid production and composition in oilseed crops
Unusual fatty acids are useful in the production of foods, biofuels, and feedstocks for industrial chemicals. Existing plants that accumulate meaningful amounts of desired unusual fatty acids such as hydroxy fatty acids are either banned in the US (Ricinus communis) or are...
Published: 4/8/2026
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Inventor(s): Phil Bates, Sajina Bhandari, Prasad Parchuri, Abdul Azeez
Keywords(s): Biofuels, Bioproducts, Biotechnology, fatty acid, Metabolic engineering, Plant Based Products
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Foldable Polymers as Gene Probes
Abstract
This technology utilizes novel probes to detect and identify target biomolecules in a sample. These probes employ conformational changes induced by molecular recognition events to initiate changes in the optical properties of the probe (e.g. the modulation of a fluorescence or absorption response upon target binding). Methods, including solid...
Published: 4/8/2026
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Inventor(s): Alexander Li, Wei Wang
Keywords(s): Advanced Materials, Biotechnology
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A NATURAL ANTIMICROBIAL TO CONTROL PATHOGENIC E. COLI
AbstractHarmful strains of Escherichia coli bacteria, primarily found in cattle cause severe, sometimes life-threatening human illness. According to the US Centers for Disease Control and Prevention, an estimated 110,000 cases (due to specifically enterohaemorrhagic E. coli (EHEC)) occur annually in the United States, and is now plaguing more than 30...
Published: 4/8/2026
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Inventor(s): Douglas Call, Lauren Eberhart, Kelly Brayton, Thomas Besser, Ashish Sawant, Lisa Orfe
Keywords(s): Biotechnology, Veterinary
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Real-time PCR primers for native yeasts of grape
Monitoring Native Yeast Populations in VineyardsUnmet Need: Effective strategy to identify and quantify native Yeast populationsNative yeasts are part of the microbial community in grape vineyards and play roles in alcoholic fermentation and wine quality. Monitoring their populations during fermentation and after bottling is important as it will provide...
Published: 4/8/2026
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Inventor(s): Xuefei Wang, Patricia Okubara
Keywords(s): Agriculture and Plant Sciences, Biotechnology, Diagnostics, Technology
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Whole transcriptome start site sequencing (WTSS-seq) method
Unmet Need: Effective methods for genetic profilingRNA contributes significantly to the complexity of information transfer from genome to phenome. Alternative transcripts have been considered as biomarkers for improved early diagnosis of diseases, and as targets for designing novel treatment options. Recent studies have revealed that the transcriptome...
Published: 4/8/2026
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Inventor(s): Zhihua Jiang, Jennifer Michal, Xiang Zhou
Keywords(s): Biotechnology, Diagnostics, High throughput, Tool
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Anti-inflammatory activity by Doxorubicin-Conjugated Nanoparticles
Unmet Need: Effective therapy for inflammatory disorders. Inflammation is a key physiological response to bacterial and viral infections. Neutrophils are an important part of the innate immune response and normally maintain a constant population by undergoing spontaneous apoptosis after a short lifespan of 8-20 hours. However, it is well known that...
Published: 4/8/2026
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Inventor(s): Zhenjia Wang, Canyang Zhang
Keywords(s): Biotechnology
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Production of Complex Flavonoids
Unmet Need: Production of lipophilic methoxylated flavonoids
Numerous methoxylated flavonoids exhibit pronounced bioactivities. Their biotechnological production and diversification are therefore of interest to pharmaceutical and nutraceutical industries. Efforts to engineer flavonoid mechanisms have been conducted earlier but there has not been much...
Published: 4/8/2026
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Inventor(s): David Gang, Anna Berim
Keywords(s): Biotechnology, Engineering, Natural products
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Calcium/Calmodulin-Regulated Plant Immunity
Unmet Need: Understanding the mechanism of regulation of salicylic acid by Ca2+ signaling Intracellular calcium transients during plant-pathogen interactions are necessary early events leading to local and systemic acquired resistance. Salicylic acid, a critical messenger, is also required for both these responses, but whether and how salicylic acid...
Published: 4/8/2026
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Inventor(s): B Poovaiah, A Reddy, Gul Ali, Tianbao Yang, Kayla Simons, Jingguo Hou, Liqun Du
Keywords(s): Agriculture and Plant Sciences, Biotechnology
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