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Targeting ARRDC5 for Male Contraception
Unmet Need: ARRDC5, an essential regulator of mammalian spermatogenesis
Identification of a molecule arrestin-domain containing ARRDC5 as an essential regulator of mammalian spermatogenesis, which could potentially be targeted for the development of male contraceptives. By studying mice lacking the ARRDC5 gene, inventors observed that mice were infertile...
Published: 6/18/2024
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Inventor(s): Jon Oatley, Mariana Ianello Giassetti
Keywords(s): Biotechnology, Contraception, Sperm
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Mice with humanized telomere homeostasis
Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis
Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...
Published: 1/9/2024
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Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng
Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase
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Paper-based cationic isotachophoresis for lateral flow immunoassay development
Unmet Need: Improving sensitivity and specificity in Lateral Flow Immunoassays at low concentrations
Lateral flow immunoassays (LFIAs) are among the most popular diagnostic platforms on the market due to ease of use and capacity for antigen detection in diverse biological samples. However, they are often critiqued for their relatively high limits of...
Published: 9/21/2023
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Inventor(s): Wenji Dong, Devon McCornack
Keywords(s): Adsorption, Applied Technologies, biosensors, Biotechnology, Cancer and aging, Cationic Isotachophresis, depletion of abundant serum proteins, Nanotechnology, Purification, Real time virus sensor
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New Oilseed Remodeling
Unmet Need: Improved fatty acid production and composition in oilseed crops
Unusual fatty acids are useful in the production of foods, biofuels, and feedstocks for industrial chemicals. Existing plants that accumulate meaningful amounts of desired unusual fatty acids such as hydroxy fatty acids are either banned in the US (Ricinus communis) or are...
Published: 2/15/2024
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Inventor(s): Phil Bates, Sajina Bhandari, Prasad Parchuri, Abdul Azeez
Keywords(s): Biofuels, Bioproducts, Biotechnology, fatty acid, Metabolic engineering, Plant Based Products
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Foldable Polymers as Gene Probes
Abstract
This technology utilizes novel probes to detect and identify target biomolecules in a sample. These probes employ conformational changes induced by molecular recognition events to initiate changes in the optical properties of the probe (e.g. the modulation of a fluorescence or absorption response upon target binding). Methods, including solid...
Published: 5/25/2023
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Inventor(s): Alexander Li, Wei Wang
Keywords(s): Advanced Materials, Biotechnology
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A NATURAL ANTIMICROBIAL TO CONTROL PATHOGENIC E. COLI
AbstractHarmful strains of Escherichia coli bacteria, primarily found in cattle cause severe, sometimes life-threatening human illness. According to the US Centers for Disease Control and Prevention, an estimated 110,000 cases (due to specifically enterohaemorrhagic E. coli (EHEC)) occur annually in the United States, and is now plaguing more than 30...
Published: 7/5/2023
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Inventor(s): Douglas Call, Lauren Eberhart, Kelly Brayton, Thomas Besser, Ashish Sawant, Lisa Orfe
Keywords(s): Biotechnology, Veterinary
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Real-time PCR primers for native yeasts of grape
Monitoring Native Yeast Populations in VineyardsUnmet Need: Effective strategy to identify and quantify native Yeast populationsNative yeasts are part of the microbial community in grape vineyards and play roles in alcoholic fermentation and wine quality. Monitoring their populations during fermentation and after bottling is important as it will provide...
Published: 4/28/2023
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Inventor(s): Xuefei Wang, Patricia Okubara
Keywords(s): Agriculture and Plant Sciences, Biotechnology, Diagnostics, Technology
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Whole transcriptome start site sequencing (WTSS-seq) method
Unmet Need: Effective methods for genetic profilingRNA contributes significantly to the complexity of information transfer from genome to phenome. Alternative transcripts have been considered as biomarkers for improved early diagnosis of diseases, and as targets for designing novel treatment options. Recent studies have revealed that the transcriptome...
Published: 10/27/2021
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Inventor(s): Zhihua Jiang, Jennifer Michal, Xiang Zhou
Keywords(s): Biotechnology, Diagnostics, High throughput, Tool
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Fungus for control of Varroa mites in Honeybees
Unmet Need: Effective controlling agents for Varroa mitesVarroa mites are a devastating parasite considered the top driver of honey bee colony losses over the past several decades. Products for varroa control are desperately needed. The general idea of using entomopathogenic fungi to control Varroa mites had been explored previously. However, none...
Published: 5/26/2023
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Inventor(s): Nicholas Naeger, Jennifer Han, Walter Sheppard, Lori Carris
Keywords(s): Agriculture, Biotechnology
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Anti-inflammatory activity by Doxorubicin-Conjugated Nanoparticles
Unmet Need: Effective therapy for inflammatory disorders. Inflammation is a key physiological response to bacterial and viral infections. Neutrophils are an important part of the innate immune response and normally maintain a constant population by undergoing spontaneous apoptosis after a short lifespan of 8-20 hours. However, it is well known that...
Published: 4/28/2023
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Inventor(s): Zhenjia Wang, Canyang Zhang
Keywords(s): Biotechnology
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