Elderberry-Derived Anthocyanin Compositions for weight management

Unmet Need: Developing effective, evidence-backed tools for weight management

Obesity occurs in more than 40% of Americans and contributes to more than $170 billion in medical expenses annually, primarily via increased incidence of heart disease, type 2 diabetes, and breathing issues. Unsurprisingly, the weight loss industry is booming in the United States and estimated to grow at a CAGR of nearly 10% to $305 billion by 2030. Despite some recent pharmaceutical successes such as GLP-1 agonists, obesity remains a huge driver of the US economy and health system.

Thus, continued innovation in weight management is important to combatting the obesity epidemic. Anthocyanins, such as those found in berries and other fruits have been linked to healthy weight maintenance in many translational and clinical studies. Researchers at WSU have assessed the effect of anthocyanins from American black elderberries (Sambucus canadensis) on the development of diet-induced obesity in rodents. Their findings reveal that elderberry juice is a potent mediator of diet-induced obesity, either alone or in conjunction with physical activity.

The Technology: The anthocyanin profile of Sambucus canadensis promotes healthy weight management

Despite significant evidence that European elderberry (Sambucus nigra) anthocyanins support immune health, the potential health benefits of the related American black elderberry (Sambucus canadensis) remain largely unevaluated. Researchers at WSU conducted a series of experiments using anthocyanins and other bioactive constituents of Sambucus canadensis juice within a high-fat diet. Researchers demonstrated a protective effect on diet-induced obesity by conducting a rodent feeding study. Their findings suggest that the anthocyanin profile of Sambucus canadensis is a potent inhibitor of diet-induced obesity independent of physical activity level.

Additionally, researchers observed significant modulation of the gut microbiome, suggesting further application of this supplement as a potent prebiotic modulating Bifidobacterium, Anaeroplasma, and Desulfovibrio species.

Applications:

Nutrition and dietary supplements for weight management
Prebiotic supplements for gut health
Holistic wellness and nutrition

Advantages:

Mediates obesity within a high-fat diet
Positive modulator of gut microbiome
Naturally derived, attractive to populations hesitant about pharmaceutical intervention

Patent Information:

A provisional patent application has been filed.