invention relates to a compact, lab-on-a-chip sensor platform to detect multiple
cardiac biomarkers from microliter bloods samples. Optical characterization of
cardiac biomarkers in will lay the groundwork for development of novel optical
devices for detection and analysis of biomedically important molecules important
for disease diagnosis.
platform integrates sample preprocessing through a nanofluidic field effect
transistor (FET) electrofocusing unit with resonant optical detection based on
silicon microrings. The combination of immunoaffinity-based resonant optical
sensing with extensive sample purification and concentration on a multi-gated
FET nanochannel array is expected to produce very high sensitivities capable of
quantifying even ultra-trace biomarkers.
a simple, quantitative, fast, high-throughput, label-free, highly targeted
detection of sub-ng/ml concentrations of cardiac