Hydrogen Sulfide Releasing Agents

Abstract

Hydrogen sulfide (H₂S) has demonstrated several essential critical care benefits when delivered properly in low doses. The current state of the art delivery systems rely on gaseous delivery of H₂S to patients. WSU researchers have developed chemical agents that controllably decompose to release H₂S and demonstrated their efficacy in biological tissues. 

Applications and Advantages

§   Timed-release 

§   Biocompatible

IP Status 

US patent application pending and PCT/US2011/062820 published as WO2012/05242

Publications

Zhao, Y.; Wang, H.; Xian, M.; Cysteine activated hydrogen sulfide (H2S) donors. J. Am. Chem. Soc.,  2011, 133, 15.

Zhao, Y.; Bhushan, S.; Yang, C.; Otsuka, H.; Stein, J.D.; Pacheco, A.; Peng, B.; Devarie, N.O.; Aguilar, HC; Lefer, D.J.; Xian, M.; Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury.  ACS Chem. Biol. 2013, in press.

See trade magazine article at: http://cen.acs.org/articles/91/web/2013/04/Hydrogen-Sulfide-Donors-Protect-Heart.html 

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