|
Gas Phase Mobility Selection of Ions Prior to Mass Spectrometric Analysis
Abstract Traditionally, ion mobility spectrometry (IMS) has been used for the analysis of gas phase compounds, however, with the advent of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) the technique's scope of analysis has greatly expanded. The powerful prospects of combining IMS and ion mobility mass spectrometry...
Published: 5/25/2023
|
Inventor(s): Brian Clowers, Herbert Hill
Keywords(s): Instrumentation/Equipment
|
|
Tailored, Non-linear Signal Modulation for Encoding Information in Multiple Dimensions
Unmet Need: Fast, multidimensional analysis of the physical, chemical, and mechanical properties of gas-phase ions, molecules, and particles
When coupling two or more stages of on-line or off-line analysis, the second stage of analysis must be much faster than the first to adequately sample information transmitted between dimensions. When the second...
Published: 5/25/2023
|
Inventor(s): Brian Clowers, Elvin Cabrera, David Russell, Arthur Laganowsky
Keywords(s): Ion Mobility Spectrometry, Mass Spectrometry, Signal Processing
|
|
A Two-Phase Approach for Time-Domain Ion Mobility Mass Spectrometry
SummaryDrift-tube ion mobility spectrometry (DT-IMS) is largely unmatched in its ability to rapidly screen passengers, cargo, and the surrounding environment for narcotics, explosives, and chemical warfare agents. However, DT-IMS are limited by duty cycle. Most experiments are on the order of < 1%, and this limitation impacts sensitivity. In addition,...
Published: 5/25/2023
|
Inventor(s): Brian Clowers, William Siems
Keywords(s):
|
|
Breathalyzer for Psychoactive drugs
Unmet Need: Lack of reliable on site detection method for psychoactive drugs
Rapid detection of drugs of abuse in the field requires innovative approaches for collection and detection. Current approaches such as collection of blood, saliva, urine, sweat, or other bodily fluids may seem attractive but also have the potential to collect identifying...
Published: 1/5/2024
|
Inventor(s): Herbert Hill, Brian Clowers
Keywords(s):
|